They do not have the same result if they actually need that margin to get to those sizes.
If you are trading two standard lots, you are trading 20,000 units. If you must use 50 to 1 leverage to trade 20,000 units your account value is 400 units (20,000/50=400). A trader in this situation will lose $2 per pip and thus need to lose 200 pips to be wiped out. He is risking .50% of his account per pip.
If you are trading one standard lot, you are trading 10,000 units. If you must use 100 to 1 leverage to trade 10,000 units your account value is 100 units (10,000/100=100). A trader in this situation will lose $1 per pip and thus need to lose 100 pips to be wiped out. He is risking 1% of his account per pip.
In terms of the percent of the account risked per pip, the second trader is at greater risk than the first and would be wiped out with a smaller move against him. 100 pips would wipe out the second trader while the first would only be down 50%.
But you may be asking a different question than the one I answered here.