Personally i wouldn`t bother with either, the spreads going to eat half your profits,
but to try and answer your question, generally, a low risk to large profit ratio is better,
So say for instance there was a trade where you were risking 50 pips to make 150.
that would be better then risking 150 to make 50.
It would take 3 losses to get back to where you started - spread.
the other way it would be 1 loss to wipe out your winnings from 3 trades.
I`m sure that short term traders such as scalpers will give you a different answer, but in general i trade longer term trades are open for several days.